Vincristine Side Effects With Concomitant Fluconazole Use During Induction Chemotherapy in Pediatric Acute Lymphoblastic Leukemia.

As a mainstay of treatment for acute lymphoblastic leukemia (ALL), vincristine's side effect profile is well known. Parallel administration of the antifungal fluconazole has been shown to interfere with the metabolism of vincristine, potentially resulting in increased side effects. We conducted a retrospective chart review to determine whether concomitant administration of vincristine and fluconazole during pediatric ALL induction therapy impacted the frequency of vincristine side effects, namely, hyponatremia and peripheral neuropathy. We also evaluated whether the incidence of opportunistic fungal infections was impacted by fluconazole prophylaxis. Medical charts of all pediatric ALL patients treated with induction chemotherapy at Children's Hospital and Medical Center in Omaha, NE, from 2013 to 2021 were retrospectively reviewed. Fluconazole prophylaxis did not significantly impact the rate of fungal infections. We found no correlation between fluconazole use and increased incidence of hyponatremia or peripheral neuropathy, which supports the safety of fungal prophylaxis with fluconazole during pediatric ALL induction therapy.

[Total laparoscopic hysterectomy (TLH): results at a tertiary referral hospital]. / Histerectomía total laparoscópica: resultados en un hospital de tercer nivel de atención.

BACKGROUND: The laparoscopic total hysterectomy is an increasingly applied alternative in the surgical management of uterine pathology. OBJECTIVE: To describe the results obtained in patients that underwent total laparoscopic hysterectomy for the management of benign uterine pathology. MATERIAL AND METHOD: We performed a descriptive, longitudinal and retrospective study in which results on 151 patients who underwent total laparoscopic hysterectomy between October 2008 and July 2011 are reported. RESULTS: The average age of the population was 42.5 years (30-56 years); body mass index averaged 25.8 kg/m2 (18-37 kg/m2). The most common surgical indication was uterine fibroids in 121 cases (80.1%). Among the surgical outcomes, the average operative time was 140.3 minutes (70-275 minutes); average total bleeding, 131 mL (50-400 mL); 3 cases (1.98%) of bladder injury were reported. The immediate postoperative evolution was hospitalization of 1.4 days (1-7 days). Late postoperative complications were fistulas of the urinary tract in 7 cases (4.63%), and in 1 case (0.66%) infection of the vaginal vault. The average weight of surgical specimens was 210 g (50-650 g). CONCLUSIONS: Total laparoscopic hysterectomy is an appropriate therapeutic option We believe that careful selection of patients is critical to providing the best results.

Conocimiento y actitudes hacia el infectado con VIH y su relación con la conducta sexual de riesgo en estudiantes de secundaria de los colegios mixtos: José Sabogal de Lima y Mariano Bonin de Tingo María - Huánuco / Knowledge and attitudes towards infected with VIH and the their relation with the sexual conduct of risk in students of secondary of the mixed schools: Jose Sabogal de Lima and Mariano Bonin de Tingo Maria - Huánuco

El presente trabajo esta dirigido a determinar los conocimientos sobre la infección VIH y medidas preventivas en estudiantes de dos colegios mixtos: José Sabogal de Lima y Mariano Bonin de Tingo María - Huánuco, en alumnos de 3º, 4º y 5º año de secundaria, siendo por cada colegio 154 alumnos entre ambos sexos. El método empleado fue el comparativo de corte transversal. Antes de aplicar el instrumento se realizó un estudio piloto a 50 alumnos de otro colegio. Los resultados hallados fueron: en el colegio José Sabogal de Lima el 40,3 por ciento tienen conocimiento regular y 36,3 por ciento tienen conocimiento bueno; la actitud hacia el infectado con VIH es indecisa y favorable; la conducta sexual es de riesgo en 58,4 por ciento y no riesgo 41,6 por ciento. En el colegio Mariano Bonin de Tingo María - Huánuco el nivel de conocimiento es regular (45,4 por ciento y malo 36,4) la actitud hacia los infectados con VIH es indecisa 66,9 y desfavorable 25,3 por ciento la conducta sexual es de riesgo prioritariamente.